[HTML][HTML] Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function
RA Colvin, GSV Campanella, J Sun… - Journal of Biological …, 2004 - ASBMB
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T
cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and
CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most
potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3
internalization after T cell contact with activated endothelial cells. We have therefore
hypothesized that these three ligands transduce different signals to CXCR3. In light of this …
cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and
CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most
potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3
internalization after T cell contact with activated endothelial cells. We have therefore
hypothesized that these three ligands transduce different signals to CXCR3. In light of this …