[HTML][HTML] miRiad roles for the miR-17-92 cluster in development and disease
JT Mendell - Cell, 2008 - cell.com
Cell, 2008•cell.com
MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act
as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses
apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential
functions for these miRNAs not only in tumor formation but also during normal development
of the heart, lungs, and immune system.
as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses
apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential
functions for these miRNAs not only in tumor formation but also during normal development
of the heart, lungs, and immune system.
MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.
cell.com