[HTML][HTML] Endotoxin priming of neutrophils requires NADPH oxidase-generated oxidants and is regulated by the anion transporter ClC-3

JG Moreland, AP Davis, JJ Matsuda, JS Hook… - Journal of biological …, 2007 - ASBMB
Several soluble mediators, including endotoxin, prime neutrophils for an enhanced
respiratory burst in response to subsequent stimulation. Priming of neutrophils occurs in
vitro, and primed neutrophils are found in vivo. We previously localized the anion transporter
ClC-3 to polymorphonuclear leukocytes (PMN) secretory vesicles and demonstrated that it is
required for normal NADPH oxidase activation in response to both particulate and soluble
stimuli. We now explore the contribution of the NADPH oxidase and ClC-3 to endotoxin …