The Id3 gene has been shown to play important roles in the development and function of
broad tissue types including B and T cells. Id3 deficient mice develop autoimmune disease
similar to human Sjögren's syndrome. Both B and T lymphocytes have been implicated to
contribute to the disease phenotype in this disease model. In order to gain a better
understanding of individual cell types in this disease model, we generated an Id3
conditional allele. An LckCre transgene was used to induce Id3 deletion in developing T …