[HTML][HTML] Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane
LP Pulagam, K Palczewski - Journal of biological chemistry, 2010 - ASBMB
Rhodopsin is the rod photoreceptor G protein-coupled receptor responsible for capturing
light. Mutations in the gene encoding this protein can lead to a blinding disease called
retinitis pigmentosa, which is inherited frequently in an autosomal dominant manner. The
E150K opsin mutant associated with rarely occurring autosomal recessive retinitis
pigmentosa localizes to trans-Golgi network membranes rather than to plasma membranes
of rod photoreceptor cells. We investigated the molecular mechanisms underlying opsin …
light. Mutations in the gene encoding this protein can lead to a blinding disease called
retinitis pigmentosa, which is inherited frequently in an autosomal dominant manner. The
E150K opsin mutant associated with rarely occurring autosomal recessive retinitis
pigmentosa localizes to trans-Golgi network membranes rather than to plasma membranes
of rod photoreceptor cells. We investigated the molecular mechanisms underlying opsin …