[HTML][HTML] Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-γ expression, and diminished pro-osteogenic Wnt …

M Almeida, E Ambrogini, L Han, SC Manolagas… - Journal of Biological …, 2009 - ASBMB
Loss of bone mass with advancing age in mice is because of decreased osteoblast number
and is associated with increased oxidative stress and decreased canonical Wnt signaling.
However, the underlying mechanisms are poorly understood. We report an age-related
increase in the lipid oxidation product 4-hydroxynonenal (4-HNE) as well as increased
expression of lipoxygenase and peroxisome proliferator-activated receptor-γ (PPARγ) in the
murine skeleton. These changes together with decreased Wnt signaling are reproduced in 4 …