[HTML][HTML] Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor-to forkhead box O-mediated transcription
M Almeida, L Han, M Martin-Millan, CA O'Brien… - Journal of Biological …, 2007 - ASBMB
We have elucidated that oxidative stress is a pivotal pathogenetic factor of age-related bone
loss and strength in mice, leading to, among other changes, a decrease in osteoblast
number and bone formation. To gain insight into the molecular mechanism by which
oxidative stress exerts such adverse effects, we have tested the hypothesis that induction of
the Forkhead box O (FoxO) transcription factors by reactive oxygen species may antagonize
Wnt signaling, an essential stimulus for osteoblastogenesis. In support of this hypothesis, we …
loss and strength in mice, leading to, among other changes, a decrease in osteoblast
number and bone formation. To gain insight into the molecular mechanism by which
oxidative stress exerts such adverse effects, we have tested the hypothesis that induction of
the Forkhead box O (FoxO) transcription factors by reactive oxygen species may antagonize
Wnt signaling, an essential stimulus for osteoblastogenesis. In support of this hypothesis, we …