[HTML][HTML] Wnt/β-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor α

VJ Armstrong, M Muzylak, A Sunters, G Zaman… - Journal of Biological …, 2007 - ASBMB
The Wnt/β-catenin pathway has been implicated in bone cell response to their mechanical
environment. This response is the origin of the mechanism by which bone cells adjust bone
architecture to maintain bone strength. Osteoporosis is the most widespread failure of this
mechanism. The degree of osteoporotic bone loss in men and women is related to bio-
available estrogen. Here we report that in osteoblastic ROS 17/2.8 cells and primary
osteoblast cultures, a single short period of dynamic mechanical strain, as well as the …