[HTML][HTML] Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
M Elemans, NK Seich al Basatena… - PLoS computational …, 2011 - journals.plos.org
M Elemans, NK Seich al Basatena, NR Klatt, C Gkekas, G Silvestri, B Asquith
PLoS computational biology, 2011•journals.plos.orgIn January 2010 two groups independently published the observation that the depletion of
CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of
productively infected cells. This unexpected observation led the authors to suggest that
CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of
alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were
proposed. This left the field with no consensus on how to interpret these experiments and no …
CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of
productively infected cells. This unexpected observation led the authors to suggest that
CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of
alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were
proposed. This left the field with no consensus on how to interpret these experiments and no …
In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
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