Successful treatment of resistant pseudogout with anakinra
D McGonagle, AL Tan, J Madden… - … : Official Journal of …, 2008 - Wiley Online Library
Arthritis & Rheumatism: Official Journal of the American College …, 2008•Wiley Online Library
We describe herein the case of a 63‐year‐old man with pseudogout affecting multiple joints
that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based
on recent data on the molecular mechanism of pseudogout that demonstrated
overproduction of interleukin‐1 (IL‐1), we treated the patient with anakinra, an IL‐1 receptor
antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution
of the signs and symptoms of pseudogout and normalization of levels of inflammation …
that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based
on recent data on the molecular mechanism of pseudogout that demonstrated
overproduction of interleukin‐1 (IL‐1), we treated the patient with anakinra, an IL‐1 receptor
antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution
of the signs and symptoms of pseudogout and normalization of levels of inflammation …
Abstract
We describe herein the case of a 63‐year‐old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin‐1 (IL‐1), we treated the patient with anakinra, an IL‐1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.
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