Interleukin-1β and the autoinflammatory diseases
CA Dinarello - New England Journal of Medicine, 2009 - Mass Medical Soc
CA Dinarello
New England Journal of Medicine, 2009•Mass Medical SocInterleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia,
and other constitutional symptoms but also tissue damage and remodeling. All these effects—
including joint destruction, tissue remodeling, and elevated levels of markers of systemic
inflammation—can be reversed or reduced by specific blockade of interleukin-1 activity.
Interleukin-1 induces the expression of several other proinflammatory genes, but cytokine-
mediated inflammation can also evoke the expression of genes encoding antiinflammatory …
and other constitutional symptoms but also tissue damage and remodeling. All these effects—
including joint destruction, tissue remodeling, and elevated levels of markers of systemic
inflammation—can be reversed or reduced by specific blockade of interleukin-1 activity.
Interleukin-1 induces the expression of several other proinflammatory genes, but cytokine-
mediated inflammation can also evoke the expression of genes encoding antiinflammatory …
Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia, and other constitutional symptoms but also tissue damage and remodeling. All these effects — including joint destruction, tissue remodeling, and elevated levels of markers of systemic inflammation — can be reversed or reduced by specific blockade of interleukin-1 activity.
Interleukin-1 induces the expression of several other proinflammatory genes, but cytokine-mediated inflammation can also evoke the expression of genes encoding antiinflammatory proteins that nonspecifically suppress inflammation. In the case of interleukin-1, however, a particular molecule that specifically inhibits interleukin-1 activity is induced. The 11 members of the interleukin-1 . . .
The New England Journal Of Medicine