[HTML][HTML] Wnt signaling controls the phosphorylation status of β-catenin
M van Noort, J Meeldijk, R van der Zee… - Journal of Biological …, 2002 - ASBMB
At the heart of the canonical Wnt signaling cascade, adenomatous polyposis coli (APC),
axin, and GSK3 constitute the so-called destruction complex, which controls the stability of β-
catenin. It is generally believed that four conserved Ser/Thr residues in the N terminus of β-
catenin are the pivotal targets for the constitutively active serine kinase GSK3. In cells that do
not receive Wnt signals, glycogen synthase kinase (GSK) is presumed to phosphorylate β-
catenin, thus marking the latter for proteasomal degradation. Wnt signaling inhibits GSK3 …
axin, and GSK3 constitute the so-called destruction complex, which controls the stability of β-
catenin. It is generally believed that four conserved Ser/Thr residues in the N terminus of β-
catenin are the pivotal targets for the constitutively active serine kinase GSK3. In cells that do
not receive Wnt signals, glycogen synthase kinase (GSK) is presumed to phosphorylate β-
catenin, thus marking the latter for proteasomal degradation. Wnt signaling inhibits GSK3 …