Detection of neuritic plaques in Alzheimer's disease mouse model
PTT Ly, F Cai, W Song - JoVE (Journal of Visualized Experiments), 2011 - jove.com
Alzheimer's disease (AD) is the most common neurodegenerative disorder leading to
dementia. Neuritic plaque formation is one of the pathological hallmarks of Alzheimer's
disease. The central component of neuritic plaques is a small filamentous protein called
amyloid β protein (Aβ) 1, which is derived from sequential proteolytic cleavage of the beta-
amyloid precursor protein (APP) by β-secretase and γ-secretase. The amyloid hypothesis
entails that Aγ-containing plaques as the underlying toxic mechanism in AD pathology2. The …
dementia. Neuritic plaque formation is one of the pathological hallmarks of Alzheimer's
disease. The central component of neuritic plaques is a small filamentous protein called
amyloid β protein (Aβ) 1, which is derived from sequential proteolytic cleavage of the beta-
amyloid precursor protein (APP) by β-secretase and γ-secretase. The amyloid hypothesis
entails that Aγ-containing plaques as the underlying toxic mechanism in AD pathology2. The …