Context In many cancers, specific subpopulations of cells appear to be uniquely capable of
initiating and maintaining tumors. The strongest support for this cancer stem cell model
comes from transplantation assays in immunodeficient mice, which indicate that human
acute myeloid leukemia (AML) is driven by self-renewing leukemic stem cells (LSCs). This
model has significant implications for the development of novel therapies, but its clinical
relevance has yet to be determined. Objective To identify an LSC gene expression signature …