Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells
SP Chang, SC Shen, WR Lee, LL Yang… - Journal of Dermatological …, 2011 - Elsevier
BACKGROUND: Imatinib mesylate (STI571), a protein tyrosine kinase inhibitor, was shown
to reduce the viability of several cancer cell lines via apoptosis induction; however, the role
of reactive oxygen species (ROS) in STI571-induced melanoma cell apoptosis is still
undefined. OBJECTIVE: In this study, we investigated the contribution of ROS to STI571-
induced apoptosis in melanoma B16F0 cells, and the apoptotic mechanism elicited by
STI571 was illustrated. METHODS: Using an in vitro cell culture system, the effects of STI571 …
to reduce the viability of several cancer cell lines via apoptosis induction; however, the role
of reactive oxygen species (ROS) in STI571-induced melanoma cell apoptosis is still
undefined. OBJECTIVE: In this study, we investigated the contribution of ROS to STI571-
induced apoptosis in melanoma B16F0 cells, and the apoptotic mechanism elicited by
STI571 was illustrated. METHODS: Using an in vitro cell culture system, the effects of STI571 …