The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice
AN Chawira, DC Warhurst, BL Robinson… - Transactions of the Royal …, 1987 - Elsevier
Artemisinin is a novel antimalarial drug isolated in China from the wormwood plant Artemisia
annua L. Studies with rodent malaria were carried out to detect antagonism and synergism
with a variety of antimalarial drugs. Isobolograms of drug interaction were plotted at the ED
90 level. With a normally susceptible strain of Plasmodium berghei, marked potentiative
synergism was found with mefloquine, tetracycline and spiramycin. There was some
synergism also with primaquine. Combinations of artemisinin with dapsone, sulfadiazine …
annua L. Studies with rodent malaria were carried out to detect antagonism and synergism
with a variety of antimalarial drugs. Isobolograms of drug interaction were plotted at the ED
90 level. With a normally susceptible strain of Plasmodium berghei, marked potentiative
synergism was found with mefloquine, tetracycline and spiramycin. There was some
synergism also with primaquine. Combinations of artemisinin with dapsone, sulfadiazine …