[HTML][HTML] Junctional adhesion molecule 1 regulates epithelial cell morphology through effects on β1 integrins and Rap1 activity
Epithelial tight junctions form a selectively permeable barrier to ions and small molecules.
Junctional adhesion molecule 1 (JAM1/JAM-A/F11R) is a tight junction-associated
transmembrane protein that has been shown to participate in the regulation of epithelial
barrier function. In a recent study, we presented evidence suggesting that JAM1 homodimer
formation is critical for epithelial barrier function (Mandell, KJ, McCall, IC, and Parkos, CA
(2004) J. Biol. Chem. 279, 16254–16262). Here we have used small interfering RNA to …
Junctional adhesion molecule 1 (JAM1/JAM-A/F11R) is a tight junction-associated
transmembrane protein that has been shown to participate in the regulation of epithelial
barrier function. In a recent study, we presented evidence suggesting that JAM1 homodimer
formation is critical for epithelial barrier function (Mandell, KJ, McCall, IC, and Parkos, CA
(2004) J. Biol. Chem. 279, 16254–16262). Here we have used small interfering RNA to …