[HTML][HTML] Nitrosothiol formation catalyzed by ceruloplasmin: implication for cytoprotective mechanism in vivo
K Inoue, T Akaike, Y Miyamoto, T Okamoto… - Journal of Biological …, 1999 - ASBMB
Ceruloplasmin (CP) is a major multicopper-containing plasma protein that is not only
involved in iron metabolism through its ferroxidase activity but also functions as an
antioxidant. However, physiological substrates for CP have not been fully identified nor has
the role of CP been fully understood. The reaction of nitric oxide (NO) with CP was
investigated in view of nitrosothiol (RS-NO) formation. First, formation of heavy metal-or CP-
catalyzed RS-NO was examined with physiologically relevant concentrations of NO and …
involved in iron metabolism through its ferroxidase activity but also functions as an
antioxidant. However, physiological substrates for CP have not been fully identified nor has
the role of CP been fully understood. The reaction of nitric oxide (NO) with CP was
investigated in view of nitrosothiol (RS-NO) formation. First, formation of heavy metal-or CP-
catalyzed RS-NO was examined with physiologically relevant concentrations of NO and …