Lack of a fusion requirement for development of bone marrow-derived epithelia
RG Harris, EL Herzog, EM Bruscia, JE Grove… - Science, 2004 - science.org
Science, 2004•science.org
Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated
by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop
from BMDCs without cell-cell fusion. We use the Cre/lox system together with β-
galactosidase and enhanced green fluorescent protein expression in transgenic mice to
identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell
fusion.
by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop
from BMDCs without cell-cell fusion. We use the Cre/lox system together with β-
galactosidase and enhanced green fluorescent protein expression in transgenic mice to
identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell
fusion.
Analysis of developmental plasticity of bone marrow–derived cells (BMDCs) is complicated by the possibility of cell-cell fusion. Here we demonstrate that epithelial cells can develop from BMDCs without cell-cell fusion. We use the Cre/lox system together with β-galactosidase and enhanced green fluorescent protein expression in transgenic mice to identify epithelial cells in the lung, liver, and skin that develop from BMDCs without cell fusion.
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