[CITATION][C] Delayed afterdepolarizations in heart muscle: mechanisms and relevance.
CT January, HA Fozzard - Pharmacological reviews, 1988 - ASPET
CT January, HA Fozzard
Pharmacological reviews, 1988•ASPETTHE CELLULAR MECHANISMS that cause cardiac anrhythmias are of immense importance
and are the object of intense investigation. One mechanism postulated to cause cardiac
arrhythmias, and possibly conduction disturbances, is delayed afterdepolanizations(also
called late afterdepolanizations, oscillatory afterpotentials, or transient depolarizations).
These depolarizations are induced by Ca2 overload of the cardiac cell. In the last decade,
several review articles have been published on the subjects of delayed afterdepolarizations …
and are the object of intense investigation. One mechanism postulated to cause cardiac
arrhythmias, and possibly conduction disturbances, is delayed afterdepolanizations(also
called late afterdepolanizations, oscillatory afterpotentials, or transient depolarizations).
These depolarizations are induced by Ca2 overload of the cardiac cell. In the last decade,
several review articles have been published on the subjects of delayed afterdepolarizations …
THE CELLULAR MECHANISMS that cause cardiac anrhythmias are of immense importance and are the object of intense investigation. One mechanism postulated to cause cardiac arrhythmias, and possibly conduction disturbances, is delayed afterdepolanizations(also called late afterdepolanizations, oscillatory afterpotentials, or transient depolarizations). These depolarizations are induced by Ca2 overload of the cardiac cell. In the last decade, several review articles have been published on the subjects of delayed afterdepolarizations and of mechanisms of arrhythmias(16, 28, 86). The purpose of this review is to summarize recent experimental evidence pertinent to the mechanisms responsible for delayed afterdepolarizations and their relation to Ca2, and to gain insight into their clinical relevance.
ASPET