[HTML][HTML] Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition
M Nishida, K Watanabe, Y Sato, M Nakaya… - Journal of biological …, 2010 - ASBMB
Activation of Ca 2+ signaling induced by receptor stimulation and mechanical stress plays a
critical role in the development of cardiac hypertrophy. A canonical transient receptor
potential protein subfamily member, TRPC6, which is activated by diacylglycerol and
mechanical stretch, works as an upstream regulator of the Ca 2+ signaling pathway.
Although activation of protein kinase G (PKG) inhibits TRPC6 channel activity and cardiac
hypertrophy, respectively, it is unclear whether PKG suppresses cardiac hypertrophy …
critical role in the development of cardiac hypertrophy. A canonical transient receptor
potential protein subfamily member, TRPC6, which is activated by diacylglycerol and
mechanical stretch, works as an upstream regulator of the Ca 2+ signaling pathway.
Although activation of protein kinase G (PKG) inhibits TRPC6 channel activity and cardiac
hypertrophy, respectively, it is unclear whether PKG suppresses cardiac hypertrophy …