[HTML][HTML] S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling
S100A1, a 21-kDa dimeric Ca 2+-binding protein, is an enhancer of cardiac Ca 2+ release
and contractility and a potential therapeutic agent for the treatment of cardiomyopathy. The
role of S100A1 in skeletal muscle has been less well defined. Additionally, the precise
molecular mechanism underlying S100A1 modulation of sarcoplasmic reticulum Ca 2+
release in striated muscle has not been fully elucidated. Here, utilizing a genetic approach to
knock out S100A1, we demonstrate a direct physiological role of S100A1 in excitation …
and contractility and a potential therapeutic agent for the treatment of cardiomyopathy. The
role of S100A1 in skeletal muscle has been less well defined. Additionally, the precise
molecular mechanism underlying S100A1 modulation of sarcoplasmic reticulum Ca 2+
release in striated muscle has not been fully elucidated. Here, utilizing a genetic approach to
knock out S100A1, we demonstrate a direct physiological role of S100A1 in excitation …