[HTML][HTML] Dynamics of insulin secretion and the clinical implications for obesity and diabetes
S Seino, T Shibasaki, K Minami - The Journal of clinical …, 2011 - Am Soc Clin Investig
S Seino, T Shibasaki, K Minami
The Journal of clinical investigation, 2011•Am Soc Clin InvestigInsulin secretion is a highly dynamic process regulated by various factors including
nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied
at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism.
Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of
insulin secretion. This review focuses on our current understanding of the dynamics of
insulin secretion in vitro and in vivo and discusses their clinical relevance.
nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied
at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism.
Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of
insulin secretion. This review focuses on our current understanding of the dynamics of
insulin secretion in vitro and in vivo and discusses their clinical relevance.
Insulin secretion is a highly dynamic process regulated by various factors including nutrients, hormones, and neuronal inputs. The dynamics of insulin secretion can be studied at different levels: the single β cell, pancreatic islet, whole pancreas, and the intact organism. Studies have begun to analyze cellular and molecular mechanisms underlying dynamics of insulin secretion. This review focuses on our current understanding of the dynamics of insulin secretion in vitro and in vivo and discusses their clinical relevance.
The Journal of Clinical Investigation