Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but …
DT Joo, D Gong, JM Sonner, Z Jia… - The Journal of the …, 2001 - pubs.asahq.org
Background The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
subtype of glutamate receptor mediates fast excitatory neurotransmission in the central
nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not
certain if this inhibition contributes to the behavioral properties of these drugs. AMPA
receptors lacking the GluR2 subunit are resistant to blockade by barbiturates in vitro.
Paradoxically, GluR2 null mutant (-/-) mice are more sensitive to barbiturate-induced loss of …
subtype of glutamate receptor mediates fast excitatory neurotransmission in the central
nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not
certain if this inhibition contributes to the behavioral properties of these drugs. AMPA
receptors lacking the GluR2 subunit are resistant to blockade by barbiturates in vitro.
Paradoxically, GluR2 null mutant (-/-) mice are more sensitive to barbiturate-induced loss of …