Isobolographic Analysis of the Interactions between Midazolam and Propofol at GABAAReceptors in Embryonic Mouse Neurons
LC McAdam, JF MacDonald, BA Orser - The Journal of the …, 1998 - pubs.asahq.org
Background Clinical studies suggest that midazolam and propofol interact synergistically to
induce hypnosis, but these drugs do not interact synergistically to prevent movement in
response to noxious stimuli. The mechanisms underlying these interactions are not certain
but may occur at the level of the gamma-aminobutyric acid A (GABA (A)) receptor. Methods
The authors evaluated the interactions between propofol and midazolam in modulating
GABA (A) receptor activity in embryonic hippocampal neurons. The effects of midazolam and …
induce hypnosis, but these drugs do not interact synergistically to prevent movement in
response to noxious stimuli. The mechanisms underlying these interactions are not certain
but may occur at the level of the gamma-aminobutyric acid A (GABA (A)) receptor. Methods
The authors evaluated the interactions between propofol and midazolam in modulating
GABA (A) receptor activity in embryonic hippocampal neurons. The effects of midazolam and …