Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision
repair by binding to the xeroderma pigmentosum group C protein. To determine the structure
of human centrin-2 and to develop an understanding of molecular interactions between
centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure
of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C
peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this …