Activated microglia have been proposed to play a major role in the pathogenesis of
Huntington's Disease (HD). PK11195 is a ligand which binds selectively to peripheral
benzodiazepine binding sites, a type of receptor selectively expressed by activated
microglia in the central nervous system. Using 11C-(R)-PK11195 positron emission
tomography (PET), we have recently shown in vivo evidence of increased microglial
activation in both symptomatic and presymptomatic HD gene carriers and that the degree of …