[HTML][HTML] Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein β in old liver
LT Timchenko, E Salisbury, GL Wang, H Nguyen… - Journal of Biological …, 2006 - ASBMB
The RNA-binding protein CUGBP1 regulates translation of proteins in a variety of biological
processes. In this study, we show that aging liver increases CUGBP1 translational activities
by induction of a high molecular weight protein-protein complex of CUGBP1. The complex
contains CUGBP1, subunits α, β, and γ of the initiation translation factor eIF2, and four
proteins of the endoplasmic reticulum, eR90, CRT, eR60, and Grp78. The induction of the
CUGBP1-eIF2 complex in old livers is associated with the elevation of protein levels of …
processes. In this study, we show that aging liver increases CUGBP1 translational activities
by induction of a high molecular weight protein-protein complex of CUGBP1. The complex
contains CUGBP1, subunits α, β, and γ of the initiation translation factor eIF2, and four
proteins of the endoplasmic reticulum, eR90, CRT, eR60, and Grp78. The induction of the
CUGBP1-eIF2 complex in old livers is associated with the elevation of protein levels of …