[HTML][HTML] Overexpression of CUG triplet repeat-binding protein, CUGBP1, in mice inhibits myogenesis
NA Timchenko, R Patel, P Iakova, ZJ Cai… - Journal of Biological …, 2004 - ASBMB
Accumulation of RNA CUG repeats in myotonic dystrophy type 1 (DM1) patients leads to the
induction of a CUG-binding protein, CUGBP1, which increases translation of several
proteins that are required for myogenesis. In this paper, we examine the role of
overexpression of CUGBP1 in DM1 muscle pathology using transgenic mice that
overexpress CUGBP1 in skeletal muscle. Our data demonstrate that the elevation of
CUGBP1 in skeletal muscle causes overexpression of MEF2A and p21 to levels that are …
induction of a CUG-binding protein, CUGBP1, which increases translation of several
proteins that are required for myogenesis. In this paper, we examine the role of
overexpression of CUGBP1 in DM1 muscle pathology using transgenic mice that
overexpress CUGBP1 in skeletal muscle. Our data demonstrate that the elevation of
CUGBP1 in skeletal muscle causes overexpression of MEF2A and p21 to levels that are …