Lineage trees describe the microevolution of cells within an organism. They have been
useful in the study of B cell affinity maturation, which is based on somatic hypermutation of
immunoglobulin genes in germinal centers and selection of the resulting mutants. Our aim
was to create and implement an algorithm that can generate lineage trees from
immunoglobulin variable region gene sequences. The IgTree© program implements the
algorithm we developed, and generates lineage trees. Original sequences found in …