[HTML][HTML] Four PSM/SH2-B alternative splice variants and their differential roles in mitogenesis
N Yousaf, Y Deng, Y Kang, H Riedel - Journal of Biological Chemistry, 2001 - ASBMB
An SH2 domain originally termed SH2-B had been identified as a direct cellular binding
target of a number of mostly mitogenic receptors. The complete cellular protein, termed PSM,
and respective sequence variants share additional Pro-rich and PH regions, as well as
similarities with APS and Lnk. A role of these mediators has been implicated in signaling
pathways found downstream of growth hormone receptor and receptor tyrosine kinases,
including the insulin, insulin-like growth factor-I (IGF-I), platelet-derived growth factor …
target of a number of mostly mitogenic receptors. The complete cellular protein, termed PSM,
and respective sequence variants share additional Pro-rich and PH regions, as well as
similarities with APS and Lnk. A role of these mediators has been implicated in signaling
pathways found downstream of growth hormone receptor and receptor tyrosine kinases,
including the insulin, insulin-like growth factor-I (IGF-I), platelet-derived growth factor …