Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
CC Lewis, B Aronow, J Hutton, J Santeliz… - Journal of Allergy and …, 2009 - Elsevier
BACKGROUND: Allergic asthma results from inappropriate TH2-mediated inflammation.
Both IL-4 and IL-13 contribute to asthma pathogenesis, but IL-4 predominantly drives TH2
induction, whereas IL-13 is necessary and sufficient for allergen-induced airway
hyperresponsiveness and goblet cell hyperplasia. Although these 2 cytokines share
signaling components, the molecular mechanisms by which they mediate different phases of
the allergic asthmatic response remain elusive. OBJECTIVE: We sought to clarify the role or …
Both IL-4 and IL-13 contribute to asthma pathogenesis, but IL-4 predominantly drives TH2
induction, whereas IL-13 is necessary and sufficient for allergen-induced airway
hyperresponsiveness and goblet cell hyperplasia. Although these 2 cytokines share
signaling components, the molecular mechanisms by which they mediate different phases of
the allergic asthmatic response remain elusive. OBJECTIVE: We sought to clarify the role or …