[HTML][HTML] Immunization with adenovirus at the large intestinal mucosa as an effective vaccination strategy against sexually transmitted viral infection
Q Zhu, CW Thomson, KL Rosenthal, MR McDermott… - Mucosal …, 2008 - Elsevier
The large intestinal mucosa contains immunological structures that may potentially serve as
a site for induction of mucosal immunity against infections. Adenovirus (Ad), which is
effective in gene transfer to epithelia, may be an ideal antigen delivery system for
vaccination at the large intestinal mucosa. To investigate this potential, we immunized mice
with recombinant replication-deficient Ad through a single intracolorectal (ICR)
administration. Effective transfer of encoded genes was found in both the epithelial layer and …
a site for induction of mucosal immunity against infections. Adenovirus (Ad), which is
effective in gene transfer to epithelia, may be an ideal antigen delivery system for
vaccination at the large intestinal mucosa. To investigate this potential, we immunized mice
with recombinant replication-deficient Ad through a single intracolorectal (ICR)
administration. Effective transfer of encoded genes was found in both the epithelial layer and …