The electrical self-stimulation nearly two to phenomenon, discovered decades ago by Olds and Milner [21], has received considerable experimental the attention in area of psychopharmacology. In this field, use of self-stimulation was prompted by the possibility that drug-induced changes in responding might provide a means of relating the effects of various centrally acting compounds to biochemical changes in structures and pathways stimulated at the tip of the electrode. Application of this strategy, which employed many classes of centrally acting drugs, resulted in the evolution of what has been referred to as the" catecholamine hypothesis" of self-stimulation [16]. be The development of a catecholamine hypothesis of self-stimulation traced to several studies demonstrating that monoamine oxidase inhibitors [24], amphetamine [25, 29], and other drugs that increase central adrenergic resulted in increased of the rates tone of self-stimulation lateral hypothalamus. Conversely, administration of drugs that could be considered to decrease central adrenergic tone such[28], alpha-methyltyrosine [3, 25], disulfiram as reserpine of