Importance of functional EGF receptors in recovery from acute nephrotoxic injury

Z Wang, JK Chen, S Wang, G Moeckel… - Journal of the …, 2003 - journals.lww.com
Previous studies have demonstrated increased renal expression of EGF receptor (EGFR)
and EGFR ligands in response to acute toxic or ischemic renal tubular injury and have
indicated that exogenous administration of EGF accelerates recovery from such injury.
However, no studies to date have proved definitively an essential role for EGFR-mediated
responses in regeneration after tubule injury. To this end, waved-2 (wa-2) mice, which
contain a point mutation in EGFR that reduces receptor tyrosine kinase activity by> 90 …