Monocyte and macrophage biology: an overview
AJ Rees - Seminars in nephrology, 2010 - Elsevier
This review provides an overview of the current understanding of the biology of monocytes
and macrophages. It focuses on four rapidly advancing areas that underpin recent
conceptual advances, namely:(1) the bone marrow origins of monocytes and
macrophages,(2) monocyte heterogeneity,(3) the early inflammatory consequences of tissue
injury, and (4) current concepts of macrophage activation and their limitations.
and macrophages. It focuses on four rapidly advancing areas that underpin recent
conceptual advances, namely:(1) the bone marrow origins of monocytes and
macrophages,(2) monocyte heterogeneity,(3) the early inflammatory consequences of tissue
injury, and (4) current concepts of macrophage activation and their limitations.