[HTML][HTML] DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes [S]
CA Harris, JT Haas, RS Streeper, SJ Stone… - Journal of lipid …, 2011 - ASBMB
The total contribution of the acyl CoA: diacylglycerol acyltransferase (DGAT) enzymes,
DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.
Similarly, whether DGAT enzymes are required for lipid droplet (LD) formation is unknown.
In this study, we examined the requirement for DGAT enzymes in TG synthesis and LDs in
differentiated adipocytes with genetic deletions of DGAT1 and DGAT2. Adipocytes with a
single deletion of either enzyme were capable of TG synthesis and LD formation. In contrast …
DGAT1 and DGAT2, to mammalian triacylglycerol (TG) synthesis has not been determined.
Similarly, whether DGAT enzymes are required for lipid droplet (LD) formation is unknown.
In this study, we examined the requirement for DGAT enzymes in TG synthesis and LDs in
differentiated adipocytes with genetic deletions of DGAT1 and DGAT2. Adipocytes with a
single deletion of either enzyme were capable of TG synthesis and LD formation. In contrast …