Merkel cell carcinoma: correlation of KIT expression with survival and evaluation of KIT gene mutational status
AA Andea, R Patel, S Ponnazhagan, S Kumar… - Human pathology, 2010 - Elsevier
Merkel cell carcinoma is one of the most aggressive primary cutaneous malignancies.
Because some Merkel cell carcinomas express the receptor tyrosine kinase KIT, we aimed
to evaluate the correlation of KIT expression with the outcome and the presence of activating
mutations in the KIT gene in Merkel cell carcinoma. A total of 49 tumors from 40 patients with
a diagnosis of Merkel cell carcinoma were identified, of which 30 cases from 21 patients
were used in the study. KIT expression was assessed by immunohistochemistry on formalin …
Because some Merkel cell carcinomas express the receptor tyrosine kinase KIT, we aimed
to evaluate the correlation of KIT expression with the outcome and the presence of activating
mutations in the KIT gene in Merkel cell carcinoma. A total of 49 tumors from 40 patients with
a diagnosis of Merkel cell carcinoma were identified, of which 30 cases from 21 patients
were used in the study. KIT expression was assessed by immunohistochemistry on formalin …