[HTML][HTML] Direct extracellular contact between integrin α3β1 and TM4SF protein CD151
Previously we established that the α 3 β 1 integrin shows stable, specific, and stoichiometric
association with the TM4SF (tetraspannin) protein CD151. Here we used a membrane
impermeable cross-linking agent to show a direct association between extracellular
domains of α 3 β 1 and CD151. The α 3 β 1− CD151 association site was then mapped
using chimeric α 6/α 3 integrins and CD151/NAG2 TM4SF proteins. Complex formation
required an extracellular α 3 site (amino acids (aa) 570–705) not previously known to be …
association with the TM4SF (tetraspannin) protein CD151. Here we used a membrane
impermeable cross-linking agent to show a direct association between extracellular
domains of α 3 β 1 and CD151. The α 3 β 1− CD151 association site was then mapped
using chimeric α 6/α 3 integrins and CD151/NAG2 TM4SF proteins. Complex formation
required an extracellular α 3 site (amino acids (aa) 570–705) not previously known to be …