[HTML][HTML] Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

M Mastrogiannaki, P Matak, JRR Mathieu, S Delga… - …, 2012 - ncbi.nlm.nih.gov
M Mastrogiannaki, P Matak, JRR Mathieu, S Delga, P Mayeux, S Vaulont, C Peyssonnaux
Haematologica, 2012ncbi.nlm.nih.gov
Background Iron metabolism, regulated by the iron hormone hepcidin, and oxygen
homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We
previously reported that in mice in which both liver hypoxia-inducible factors-1 and-2 are
stabilized (the hepatocyte von Hippel-Lindau knockout mouse model), hepcidin expression
was strongly repressed and we hypothesized that hypoxia-inducible factor-2 could be the
major regulatory component contributing to the hepcidin down-regulation.
Abstract
Background
Iron metabolism, regulated by the iron hormone hepcidin, and oxygen homeostasis, dependent on hypoxia-inducible factors, are strongly interconnected. We previously reported that in mice in which both liver hypoxia-inducible factors-1 and-2 are stabilized (the hepatocyte von Hippel-Lindau knockout mouse model), hepcidin expression was strongly repressed and we hypothesized that hypoxia-inducible factor-2 could be the major regulatory component contributing to the hepcidin down-regulation.
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