Growth differentiation factor 15 in erythroid health and disease
T Tanno, P Noel, JL Miller - Current opinion in hematology, 2010 - journals.lww.com
T Tanno, P Noel, JL Miller
Current opinion in hematology, 2010•journals.lww.comIn contrast to the low levels of GDF15 expressed during normal erythropoiesis, ineffective
erythropoiesis causes high-level expression of GDF15. In patients with thalassemia and
related anemias, GDF15 expression may contribute to iron overloading or other features of
the disease phenotype.
erythropoiesis causes high-level expression of GDF15. In patients with thalassemia and
related anemias, GDF15 expression may contribute to iron overloading or other features of
the disease phenotype.
Summary
In contrast to the low levels of GDF15 expressed during normal erythropoiesis, ineffective erythropoiesis causes high-level expression of GDF15. In patients with thalassemia and related anemias, GDF15 expression may contribute to iron overloading or other features of the disease phenotype.
Lippincott Williams & Wilkins