Suppression of hepcidin during anemia requires erythropoietic activity

M Pak, MA Lopez, V Gabayan, T Ganz, S Rivera - Blood, 2006 - ashpublications.org
M Pak, MA Lopez, V Gabayan, T Ganz, S Rivera
Blood, 2006ashpublications.org
Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the
diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is
suppressed during anemia, a response that would appropriately increase the absorption of
iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed
after phlebotomy or erythropoietin administration but the suppression was reversed by
inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to …
Abstract
Hepcidin, the principal iron regulatory hormone, regulates the absorption of iron from the diet and the mobilization of iron from stores. Previous studies indicated that hepcidin is suppressed during anemia, a response that would appropriately increase the absorption of iron and its release from stores. Indeed, in the mouse model, hepcidin-1 was suppressed after phlebotomy or erythropoietin administration but the suppression was reversed by inhibitors of erythropoiesis. The suppression of hepcidin necessary to match iron supply to erythropoietic demand thus requires increased erythropoiesis and is not directly mediated by anemia, tissue hypoxia, or erythropoietin.
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