[HTML][HTML] Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis

S Lakhal, J Schödel, ARM Townsend, CW Pugh… - Journal of Biological …, 2011 - ASBMB
Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it
is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation
remain unclear. In hepatocytes, hepcidin is induced by bone morphogenetic proteins
(BMPs) through a receptor complex requiring hemojuvelin (HJV) as a co-receptor. Type II
transmembrane serine proteinase (TMPRSS6) antagonizes hepcidin induction by BMPs by
cleaving HJV from the cell membrane. Inactivating mutations in TMPRSS6 lead to elevated …