Hypoxic regulation of erythropoiesis and iron metabolism

VH Haase - American Journal of Physiology-Renal …, 2010 - journals.physiology.org
American Journal of Physiology-Renal Physiology, 2010journals.physiology.org
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the
hypoxic induction of red blood cell production. Efforts to understand the molecular basis of
oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which
is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF),
the transcription factor that regulates EPO synthesis and mediates cellular adaptation to
hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular …
The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription factor that regulates EPO synthesis and mediates cellular adaptation to hypoxia. Recent insights into the molecular mechanisms that control and integrate cellular and systemic erythropoiesis-promoting hypoxia responses and their potential as a therapeutic target for the treatment of renal anemia are discussed in this review.
American Physiological Society