[HTML][HTML] Rad54p is a chromatin remodeling enzyme required for heteroduplex DNA joint formation with chromatin
M Jaskelioff, S Van Komen, JE Krebs, P Sung… - Journal of Biological …, 2003 - ASBMB
In eukaryotic cells, the repair of DNA double-strand breaks by homologous recombination
requires a RecA-like recombinase, Rad51p, and a Swi2p/Snf2p-like ATPase, Rad54p. Here
we find that yeast Rad51p and Rad54p support robust homologous pairing between single-
stranded DNA and a chromatin donor. In contrast, bacterial RecA is incapable of catalyzing
homologous pairing with a chromatin donor. We also show that Rad54p possesses many of
the biochemical properties of bona fideATP-dependent chromatin-remodeling enzymes …
requires a RecA-like recombinase, Rad51p, and a Swi2p/Snf2p-like ATPase, Rad54p. Here
we find that yeast Rad51p and Rad54p support robust homologous pairing between single-
stranded DNA and a chromatin donor. In contrast, bacterial RecA is incapable of catalyzing
homologous pairing with a chromatin donor. We also show that Rad54p possesses many of
the biochemical properties of bona fideATP-dependent chromatin-remodeling enzymes …