[HTML][HTML] A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein
J Tang, S Wu, H Liu, R Stratt, OG Barak… - Journal of Biological …, 2004 - ASBMB
Death domain-associated protein (Daxx) is a multi-functional protein that modulates both
apoptosis and transcription. Within the nucleus, Daxx is a component of the promyelocytic
leukemia protein (PML) nuclear bodies (NBs) and interacts with a number of transcription
factors, yet its precise role in transcription remains elusive. To further define the function of
Daxx, we have isolated its interacting proteins in the nucleus using epitope-tagged affinity
purification and identified X-linked mental retardation and α-thalassaemia syndrome protein …
apoptosis and transcription. Within the nucleus, Daxx is a component of the promyelocytic
leukemia protein (PML) nuclear bodies (NBs) and interacts with a number of transcription
factors, yet its precise role in transcription remains elusive. To further define the function of
Daxx, we have isolated its interacting proteins in the nucleus using epitope-tagged affinity
purification and identified X-linked mental retardation and α-thalassaemia syndrome protein …