[HTML][HTML] Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases
H Diao, S Kon, K Iwabuchi, C Kimura, J Morimoto, D Ito… - Immunity, 2004 - cell.com
H Diao, S Kon, K Iwabuchi, C Kimura, J Morimoto, D Ito, T Segawa, M Maeda, J Hamuro…
Immunity, 2004•cell.comBoth osteopontin (OPN) and natural killer T (NKT) cells play a role in the development of
immunological disorders. We examined a functional link between OPN and NKT cells.
Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model of T cell-
mediated liver diseases. Here, we show that NKT cells secrete OPN, which augments NKT
cell activation and triggers neutrophil infiltration and activation. Thus, OPN-and NKT cell-
deficient mice were refractory to Con A-induced hepatitis. In addition, a neutralizing antibody …
immunological disorders. We examined a functional link between OPN and NKT cells.
Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model of T cell-
mediated liver diseases. Here, we show that NKT cells secrete OPN, which augments NKT
cell activation and triggers neutrophil infiltration and activation. Thus, OPN-and NKT cell-
deficient mice were refractory to Con A-induced hepatitis. In addition, a neutralizing antibody …
Abstract
Both osteopontin (OPN) and natural killer T (NKT) cells play a role in the development of immunological disorders. We examined a functional link between OPN and NKT cells. Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model of T cell-mediated liver diseases. Here, we show that NKT cells secrete OPN, which augments NKT cell activation and triggers neutrophil infiltration and activation. Thus, OPN- and NKT cell-deficient mice were refractory to Con A-induced hepatitis. In addition, a neutralizing antibody specific for a cryptic epitope of OPN, exposed by thrombin cleavage, ameliorated hepatitis. These findings identify NKT cell-derived OPN as a novel target for the treatment of inflammatory liver diseases.
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