Tolerogenic dendritic cells and the quest for transplant tolerance

AE Morelli, AW Thomson - Nature Reviews Immunology, 2007 - nature.com
AE Morelli, AW Thomson
Nature Reviews Immunology, 2007nature.com
In recent years, there has been a shift from the perception of dendritic cells (DCs) solely as
inducers of immune reactivity to the view that these cells are crucial regulators of immunity,
which includes their ability to induce and maintain tolerance. Advances in our understanding
of the phenotypical and functional plasticity of DCs, and in our ability to manipulate their
development and maturation in vitro and in vivo, has provided a basis for the therapeutic
harnessing of their inherent tolerogenicity. In this Review, we integrate the available …
Abstract
In recent years, there has been a shift from the perception of dendritic cells (DCs) solely as inducers of immune reactivity to the view that these cells are crucial regulators of immunity, which includes their ability to induce and maintain tolerance. Advances in our understanding of the phenotypical and functional plasticity of DCs, and in our ability to manipulate their development and maturation in vitro and in vivo, has provided a basis for the therapeutic harnessing of their inherent tolerogenicity. In this Review, we integrate the available information on the role of DCs in the induction of tolerance, with a focus on transplantation.
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