Neurexins are a family of transmembrane, synaptic adhesion molecules. In neurons,
neurexins bind to both sub-plasma membrane and synaptic vesicle-associated constituents
of the secretory machinery, play a key role in the organization and stabilization of the
presynaptic active zone, and help mediate docking of synaptic vesicles. We have previously
shown that neurexins, like many other protein constituents of the neurotransmitter exocytotic
machinery, are expressed in pancreatic β cells. We hypothesized that the role of neurexins …