[HTML][HTML] 5′-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics
T Tsuboi, G da Silva Xavier, I Leclerc… - Journal of Biological …, 2003 - ASBMB
Changes in 5′-AMP-activated protein kinase (AMPK) activity have recently been implicated
in the control of insulin secretion by glucose (da Silva Xavier, G., Leclerc, I., Varadi, A.,
Tsuboi, T., Moule, SK, and Rutter, GA (2003) Biochem. J. 371, 761–774). Here, we examine
the possibility that activation of AMPK may regulate distal steps in insulin secretion,
including vesicle movement and fusion with the plasma membrane. Vesicle dynamics were
imaged in single pancreatic MIN6 β-cells expressing lumen-targeted pH-insensitive yellow …
in the control of insulin secretion by glucose (da Silva Xavier, G., Leclerc, I., Varadi, A.,
Tsuboi, T., Moule, SK, and Rutter, GA (2003) Biochem. J. 371, 761–774). Here, we examine
the possibility that activation of AMPK may regulate distal steps in insulin secretion,
including vesicle movement and fusion with the plasma membrane. Vesicle dynamics were
imaged in single pancreatic MIN6 β-cells expressing lumen-targeted pH-insensitive yellow …